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Transgender young adults and families with transgender youth, together with PFLAG National and GLMA, filed a federal legal challenge against a January 2025 executive order from the Trump administration directing federal agencies to withhold funds from medical providers and institutions that provide gender-affirming medical treatments for people under nineteen.

The North Carolina Department of Public Safety has continually denied Kanautica Zayre-Brown, an incarcerated transgender woman in their custody, access to gender-affirming surgery.

Jesse Hammons was denied a commonly performed medical procedure at the University of Maryland St. Joseph Medical Center because he is transgender. The taxpayer-owned hospital claims that providing Hammons with medical care would be a violation of their religious beliefs.

Becky is a student in West Virginia who is starting high school. Three years ago, as Becky was preparing to begin middle school, West Virginia passed a law categorically banning transgender girls from participating in all school sports. Becky loves being part of a team and wanted to be able to participate in cross-country and track and field with her friends. She sued, arguing that West Virginia's law violated the Constitution and Title IX as applied to her, especially because she has received medication from the onset of puberty and has never experienced any physiological changes associated with puberty for boys. As a result of an injunction issued by the lower courts, she has been able to participate in middle school cross-country and track and field for the past three years. Becky and her mother are represented by the ACLU, the 桃子视频of West Virginia, Lambda Legal and Cooley LLP.

Four Hoosier families, joined by medical providers, are challenging an Indiana law passed in April 2023 barring access to gender-affirming care for transgender youth. Indiana is home to over 4,000 transgender adolescents and the health care targeted by this law is supported by the entire mainstream of the medical community.