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Whether the challenged patents in this case violate both patent law and the First Amendment because they reach abstract ideas and pure thought.

Whether private individuals may raise a claim that California has failed to comply with federal Medicaid requirements by suing directly under the Supremacy Clause of the Constitution.

Whether the Americans with Disabilities Act may be constitutionally applied to a religious school's retaliatory firing of a teacher terminated for reasons unrelated to religion.

Whether a criminal defendant who forgoes a plea bargain because of ineffective assistance of counsel is entitled to relief if he subsequently receives a longer sentence after conviction than the prosecutor initially offered.

Whether a jail policy of strip searching every new detainee violates the Fourth Amendment.